BioResponse DIM® (Diindolylmethane)

A natural approach to estrogen management

BioResponse® Nutrients (the trade name for BioResponse, LLC), is the originator of microencapsulated BioResponse DIM® (Diindolylmethane).  Their formulation contains pure DIM (3,3’-Diindolylmethane), not I3C (Indole-3-carbinol), an unstable precursor of DIM.

BioResponse DIM® is proven, through numerous placebo-controlled clinical trials, to support beneficial estrogen metabolism in both women and men.  This estrogen metabolism is favorable because it increases conversion of estrogen, supporting hormone balance through increased production of 2-hydroxy estrogen metabolites, also known as the ‘good’ estrogens. 

These clinical trials have documented an increase in the 2-hydroxy/16-hydroxy estrone ratio, an important indicator of healthy estrogen metabolism.

BioResponse DIM, 75 mg and 150 mg

3,3 diindolylmethane

3,3 diindolylmethane

By Fvasconcellos (talk · contribs) – Own work, Public Domain, Link



By Tomaxer – en.wikipedia, CC BY-SA 3.0, Link

BioResponse DIM® also supports the production of 2- hydroxyestrone and 2-methoxyestrone, key metabolites in men and women.

Prominent researchers have documented that this balance is an important factor in maintaining health.  Both men and women use BioResponse DIM® as an integral part of hormonal balance, helping to maintain an optimal estrogen-to-testosterone balance.  This promotes hormonal health, breast health, menstrual health and weight management, in both women and men.  It also supports prostate health.

Many of the health problems commonly associated with estrogen are actually linked to hormone imbalance and unhealthy hormone metabolism.  DIM helps regulate estrogen hormone metabolism and hormonal balance.

The problem with DIM

DIM, is an indole, originally discovered in cruciferous vegetables, like broccoli, cabbage, brussels sprouts and cauliflowers.  In its pure, crystalline state, Diindolylmethane is highly insoluble, so that no clinically meaningful absorption is possible by the human body.

So, taken in supplement form, DIM – by itself – has limited benefits.  Numerous published clinical studies have demonstrated that DIM requires microencapsulation for any meaningful absorption.

But, BioResponse® has developed an innovative, proprietary microencapsulation nutrient delivery technology, called Phytosorb®, that assures predictable absorption and sustained delivery of diindolylmethane.  It  is the first and only microencapsulated DIM that guarantees predictable absorption and clinically effective blood levels.

So, try BioResponse DIM® for yourself and feel what balance is all about.  You can order your supply here.


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.