Enervite C Defense™ from Energique®

A New Approach to Defense:

Energique’s Enervite C Defense™ boosts the immune benefits of non-GMO vitamin C with Quercetin, Rutin and Holy Basil.

• Important nutrients for normal immune and antioxidant functions.
• Featuring quercetin, combined with other bioavonoids, for healthy cytokine production and normal
  histamine levels.
• Enhanced with Ursolic Acid-rich Holy Basil, to support normal respiratory function.
• Supports adrenal hormone synthesis and balances stress response, for a healthy immune response.

Directions: As a dietary supplement, adults take 1 capsule 2 times daily, preferably with a meal, or as directed by your healthcare practitioner.

Precautions: If pregnant or breastfeeding, or have a medical condition, ask a health professional before use.  Consult a physician for use in children under 12 years of age.  Keep out of reach of children.  Do not use if tamper evident seal is broken or missing.  Store in a cool dry place.

Suggested use:
Energique’s Enervite C Defense™ is a professional-strength vitamin C supplement intended for clinical use. In addition to a 500 mg serving
of non-GMO vitamin C per capsule, the formula is augmented by the inclusion of specific bioflavonoid and triterpenoid compounds, chosen to support the most important clinical applications of vitamin C: immune support, mast cell function and general antioxidant/anti-aging potential.

These supporting ingredients include quercetin and rutin, bioflavonoids found highly concentrated in citrus fruits, in addition to an innovative addition of Holy Basil (Ocimum tenuiorum) leaf extract, concentrated to provide 2.5% ursolic acid, an antioxidant compound with many research-supported anti-aging benefits and novel immune applications.

Recently, vitamin C has generated clinical interest for its emerging role in mast cell function. Vitamin C has long been known to support
the immune system by quenching the reactive oxygen species (ROS) generated by immune activity, and a growing body of research
points to this same process as instrumental to the regulation of mast cell activity. Thus, the role of Vitamin C in immune support has
expanded to include modulating the cell-mediated Th2 response and the promotion of healthy histamine levels. The addition of
bioflavonoids quercetin and rutin, known to support healthy histamine release, provide synergistic benefits for multiple aspects of
immune system function.

Ursolic Acid is an antioxidant originally identified in apple peels, but also found relatively concentrated in the leaves of Holy Basil
(Ocimum tenuiorum). Ursolic Acid has been shown to induce growth and metabolic factors in muscle normally down-regulated during
atrophy, and in addition modulate numerous other cellular signaling factors, including nuclear factor-kappa B (NF-kB) and factors which
promote insulin sensitivity, regulate liver cell apoptosis, and increase antioxidant levels in the brain. Among its most characteristic
applications is the attenuation of muscle atrophy, an age-related process which not only slows metabolism but is increasingly shown
to accurately predict longevity. The beneficial effects of Ursolic Acid on metabolism, muscle mass, weight loss, apoptotic signaling and
antioxidant status make it an ideal complement to vitamin C for the promotion of healthy aging, and the benefits of Holy Basil as an
immune-supporting adaptogen provide an additional complement to the promotion of healthy immune system function. In sum, its
additional ingredients make Energique’s Enervite C Defense™ a versatile source of non-GMO ascorbic acid, providing a clinically relevant dose that can be tailored to support a variety of holistic applications.

References:
i Yazdani and Conti. Relationship between Vitamin C, Mast Cells and Inammation. J Nutr Food Sci 2016, 6:1. Doi:10.4172/2155-9600.1000456.
ii Park HH, Lee S, Son HY, Park SB, Kim MS, Choi EJ, Singh TS, Ha JH, Lee MG, Kim JE, Hyun MC, Kwon TK, Kim YH, Kim SH. Flavonoids inhibit histamine release and expression of proinammatory cytokines in mast cells. Arch Pharm Res. 2008 Oct;31(10):1303-11. doi: 10.1007/s12272-001-2110-5. Epub 2008 Oct 29. PMID: 18958421.
iii Seo et al 2018.
iv Seo DY, Lee SR, Heo JW, No MH, Rhee BD, Ko KS, Kwak HB, Han J. Ursolic acid in health and disease. Korean J Physiol Pharmacol. 2018
May;22(3):235-248. doi: 10.4196/kjpp.2018.22.3.235. Epub 2018 Apr 25. PMID: 29719446; PMCID: PMC5928337.
v Srikanthan P, Karlamangla AS. Muscle mass index as a predictor of longevity in older adults. Am J Med. 2014 Jun;127(6):547-53. doi:
10.1016/j.amjmed.2014.02.007. Epub 2014 Feb 18. PMID: 24561114; PMCID: PMC4035379.